Identification of plasma-based protein markers
Biomarkers provide valuable information of the organic changes underlying cognitive decline, and support the estimation of the severity, progression and course of dementia. Among the most notable biological changes in Alzheimer’s disease is the abnormal accumulation of amyloid-β peptide and tau protein in the brain. Latest research enabled the quantification of these proteins from blood plasma as well, being a promising and more accessible method as compared to the previously used PET and lumbar puncture techniques. In our research we aimed at contributing to the further development of this novel method and facilitating its clinical application by measuring individual amyloid-β and tau levels from blood plasma.
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