APOE genotyping

Although the prevalence of inherited, familial Alzheimer’s disease is low, research has identified gene variations that may increase or even reduce the probability of developing the disease. As part of our research, we examine the strongest known genetic risk factor, the APOE genotype.

References

Loy, C. T., Schofield, P. R., Turner, A. M., & Kwok, J. B. (2014). Genetics of dementia. The Lancet, 383(9919), 828-840.

Milà-Alomà, M., Suárez-Calvet, M., & Molinuevo, J. L. (2019). Latest advances in cerebrospinal fluid and blood biomarkers of Alzheimer’s disease. Therapeutic Advances in Neurological Disorders, 12, 1-23.

Serrano-Pozo, A., Das, S., & Hyman, B. T. (2021). APOE and Alzheimer’s disease: Advances in genetics, pathophysiology, and therapeutic approaches. The Lancet Neurology, 20(1), 68–80.